Transgenic Rodent Assay Dose-response Database (TRAD)

The Transgenic Rodent Assay Dose-response Database contains all available dose-response data for the Transgenic Rodent Somatic and Germ Cell Mutation Assay. The assay is used to detect agents that can induce genetic mutations and is conducted as described in the Organization for Economic Cooperation and Development (OECD) test guideline 488. The database contains data from experiments conducted using transgenic rodents (i.e., mice or rats). The experiments were aimed at assessing the mutagenic activity of selected agents (e.g., chemicals) by exposing the rodents to the compounds by various exposure routes (e.g., drinking water, food, injection, etc.). The database contains the results of animal studies that tested chemicals at two or more doses; each dataset contains data for a concurrent control. The database is useful for dose-response modeling (e.g., benchmark dose analyses) to determine a point of departure that may subsequently be used for human health hazard and/or risk assessment.

Publisher

Health Canada

Resources

4

Catalogue metadata updated

2025-11-12