Fathead minnow life cycle exposure to environmentally relevant concentrations of metformin shows no adverse effects

This study aimed to determine whether the pharmaceutical metformin had toxicological effects on the fathead minnow (Pimphales promelas) in their various life stages—from eggs to adulthood. Endpoints included survival, growth, and reproductive development. Fathead minnows were exposed to metformin at concentrations 3, 31, and 322 micrograms per liter (ug/L) for a total of approximately six months. Exposing the fish to metformin from egg stage did not adversely affect early survival and did not affect growth or development compared to the controls. There were very few significant differences in length, weight, and condition factor and it did not significantly affect maturation rate, or overall egg production. The findings of this study indicate that metformin does not adversely affect fathead minnow reproduction or cause intersex gonads. All data are a part subject of a publication containing method details, full QA/QC, interpretation, and conclusions: Parrott JL, Pacepavicius G, Shires K, Clarence S, Khan H, Gardiner M, Sullivan C, and Alaee M. 2021. Fathead minnow exposed to environmentally relevant concentrations of metformin for one life cycle show no adverse effects. FACETS 6:…

Publisher

Environment and Climate Change Canada

Resources

2

Catalogue metadata updated

2024-08-15